hélios vét. pharmaceutique
TILOMED®
Prevention and treatment of diseases caused by bacterials sensitive to Tilmicosin, in addition to Apramycin sulfate as a secondary supporter
Prevention and treatment of diseases caused by bacterials sensitive to Tilmicosin, in addition to Apramycin sulfate as a secondary supporter
| .Tilmicosin (as phosphate) | 250 gm. |
| .Apramycin sulfate | 111 gm |
| .Solvents ad. 1 liter |
Origin of the molecule:
Concentrate for oral solution contains tilmicosin, it is a semi
synthetic macrolide antibiotic obtained from tylosin which
is affecting bacterial protein synthesis, Macrolides have
been used for decades as treatment for a wide range of
infectious diseases, but their effect on respiratory infe-
ctions have been getting an increased interest.
Structure and activity:
Tilmicosin has a wide spectrum of activity against gram
positive organisms of porcine, avian and bovine origin as
well as some activity against gram-negative micro organisms, cross-resistance between tilmicosin and other
macrolide antibiotics and lincosamides has been observed,
tilmicosin may lessen antibacterial activity of ß-lactam
antibiotics.
Mode of action:
Macrolide antibiotics are bacteriostatic compounds that
reversibly bind to the 50s ribosome subunit and inhibit
mrna-directed protein synthesis of the susceptible micro
organisms, the tilmicosin spectrum of activity includes
Mycoplasma gallisepticum and Mycoplasma synoviae and
gram-positive bacteria and some gram-negative germs.
For oral administration
-Calves: 1 ml per 20 kg body weight,
administered twice daily in artificial
milk for 3-5 days.
-Poultry: 300 ml per 1000 litres of
water (75 ppm) continuously for
3 days.
-Swine: 800 ml per 1000 litres of
water (200 ppm) continuously for
5 days.
-No other source of drinking water should
be available during medication period.
-After the end of the medication period,
water supply system should be cleaned
appropriately to avoid intake of sub therapeutic amounts of the active substance
which might support development of
resistance.
The ideal location for a storage unit is a clean, dry, frost-free area, such as a farm office or utility room, animal health products should be protected from changes in temperature, sunlight, dust, moisture, animals and insects.
Not for human consumption.
For veterinary use only.
Caution:
Do not allow horses or other equines access to feeds
containing Tilmicosin.
Consult your veterinarian:
Learn more about the preventive, animal
health management and the proper use
of livestock medications.